---
description: >-
  This section will describe how to map, load and check Dosing and Exposure (PK)
  data in REACT, ADMIN UI.
---

# Dosing & Exposure (PK)

The Dosing and Exposure view allows a user to investigate pharmacokinetic (PK) parameters for the study drug

Up to three tabs are available on the dosing and exposure view:

1. **Analyte Concentration Over Time**

![Analyte Concentration Over Time](https://3564003943-files.gitbook.io/~/files/v0/b/gitbook-x-prod.appspot.com/o/spaces%2FaPy975iGMCUpGQJ0Cr1R%2Fuploads%2Fm7IvxfpnfvnjxA04al90%2Fimage.png?alt=media\&token=21e5c05f-22e4-4b20-9a14-7f1c4790262d)

This plot presents analyte concentration time dependence

One plot per analyte is displayed

Time from Administration (Hours) (x-axis) is based on the scheduled (nominal) timepoints not the actual sampling timepoints

The plot will only display if one of the non-mandatory fields: Protocol Schedule Day, Hour, Minute are mapped in the Specimen Collection data mappings

2\. **Dose Proportionality Exploration**

![Dose Proportionality Exploration](https://3564003943-files.gitbook.io/~/files/v0/b/gitbook-x-prod.appspot.com/o/spaces%2FaPy975iGMCUpGQJ0Cr1R%2Fuploads%2FhvXlkWAX7r9zkyIe3PFr%2Fimage.png?alt=media\&token=8ad5d0e1-edaa-4166-aa7e-cf43a301a74e)

The plot allows investigation of analyte concentration and duration of analyte in the subject's blood

One plot per analyte is displayed

3\. **PK-Response Exploration**

![PK-Response Exploration](https://3564003943-files.gitbook.io/~/files/v0/b/gitbook-x-prod.appspot.com/o/spaces%2FaPy975iGMCUpGQJ0Cr1R%2Fuploads%2FsLllvknauMwcauyBSjtk%2Fimage.png?alt=media\&token=a5d83ee2-8cec-4e50-9738-15226014262e)

Presents the dependency between Stacked PK Results and RECIST response (response to treatment)

One plot per analyte is displayed

The plot will only be presented if the user has:

a) Oncology package permissions

b) Recist1 and Recist2 data has been mapped and loaded into Admin UI

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For more information about the different tabs and the data they represent refer to section 5.2 in the VA HUB Guide

{% embed url="https://github.com/digital-ECMT/ACUITY_docs/blob/main/VA%20HUB%20Guide/VA-Hub%20Guide_1.0.docx" %}
**VA HUB User Guide**
{% endembed %}
